Scientists are a step closer to unveil the mystery of anti-ageing and vanish wrinkles for good. As A breakthrough in understanding human skin cells offers a pathway for new anti-ageing treatments. Discovery can also leads to how other parts of the body age.
A study, published online in the journal of investigative Dermatology, has found that the activity of a key metabolic enzyme called complex II found in the battery of the skin cells called mitochondrial significantly decreases in older skin. This discovery brings experts a step closer to developing powerful anti-ageing treatments and cosmetic products which may be tailored to counteract the decrease in the enzyme’s activity levels.
The bottom line is: The batteries in our body skin cells run down, as we age, resulting in decreased bio- energy and increased free radicals. This process reflects on our skins as fine lines, wrinkles, body sagging.
“There is now a possibility of finding anti-ageing treatments which can be tailored to differently aged and differently pigmented skin”
Professor Mark Birch-Machin
Until scientists reach the top of the ladder, and solve that mystery, The best way to go about it is to regenerate our skin batteries, which means, to give them the food they needs to stay young, and fights all sort of disease as well. I am being honest here, when it comes to ageing and wrinkles fighting, exteriorly, I don’t stick to natural only. I go full bored and loaded to fight wrinkles with every battery I have, because I ain’t ready for them yet!! 
Although I stopped using Botox for the last 3 years, I miss it’s magical effect on wrinkles, although I know all about the un magical effect either. So, to attack wrinkles internally, is to supply these cells batteries with what they need and let them help us erase wrinkles from the bottom. These are the best ways to help you do that especially if you are taking medications known to cause mitochondrial dysfunction:
Strengthening the skin cells battery (mitochondria)
1- Exercise
Exercise is important in supporting the strength of the mitochondria. Many studies has proved that exercise stimulates brain mitochondrial activity, increases mitochondrial biogenesis. (1)
2- Quercetin
In a mouse model of Alzheimer’s disease, quercetin lessened learning and memory deficits, reduced senile plaques, and counteracted mitochondrial dysfunction. Bioflavonoid quercetin has emerged as a mitochondrial-enhancing agent. Quercetin has had similar beneficial effects on the mitochondria in mouse pancreatitis cells. (2) (3)
3- Acetyl L-Carnitine and Lipoic Acid
These nutrients protect the mitochondria. Carnitine acetylation helps eliminate oxidative products from the body (4). It is called “the antioxidant’s antioxidant.” In its own right. Scientists emphasise that when there is a significant age-related mitochondrial decay in heart cells and that either ALC or lipoic acid can improve this decay single handedly. These two agents complement each other on mitochondria, however, some scientists recommend that they be taken together.
4- Coenzyme Q10 
CoQ10 comes at the top of the list of mitochondria-supporting nutrients. It acts as an electron carrier between complexes I, II, and III of the mitochondrial respiratory chain. Low levels of CoQ10serve as a marker of mitochondrial dysfunction and severe activity decline. (5)
5- Nicotinamide Riboside
Researchers have established that raising NAD+ levels in old mice rejuvenates mitochondrial function to that of young one. NAD+ is an important cellular cofactor that enhances mitochondrial function and rising it is one of the strategies to enhance mitochondrial health. (6)
6- Glucosamine
Glucosamine is a supplement well-known for its joint-supporting properties. A recent study found that glucosamine increased lifespan in animals and enhanced mitochondrial biogenesis.
7- N-Acetyl Cysteine (NAC)
NAC directly improves mitochondrial energy production efficiency and it is another mitochondrial rejuvenator. N-acetyl cysteine has inhibited the inflammatory response due to mitochondrial damage. (7)
8- Creatine Monohydrate 
Creatine monohydrate is an alternative energy source for the mitochondria. Creatine supplementation has been found to produce gains in strength, energy and muscle mass in people with various conditions and diseases.
Sources:
(1) http://www.cpmedical.net/newsletter/the-hidden-cause-of-your-health-concerns
(2) http://centraldrugsrx.com/pdf/4_Meletis_-_Mitochondria.pdf
(3) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104211/
(4) http://www.cpmedical.net/newsletter/effective-natural-solutions-for-mitochondrial-diseases
(5) http://www.ncbi.nlm.nih.gov/pubmed/20109177
(6) http://www.unboundmedicine.com/medline/journal/Hippocampus.?start=610&next=true
(7) http://www.unboundmedicine.com/medline/journal/Rheumatology%20?start=990&prev=true
